Applications of MALDI | 合法醫療器材資訊網

由ACroxatto著作·2012·被引用762次—...ofMALDI-TOFmassspectrometryinclinicaldiagnosticmicrobiology.FEMSMicrobiolRev.2012Mar;36(2):380-407.doi:10.1111/j.1574-6976.2011.00298.x.

Until recently, microbial identification in clinical diagnostic laboratories has mainly relied on conventional phenotypic and gene sequencing identification techniques. The development of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) devices has revolutionized the routine identification of microorganisms in clinical microbiology laboratories by introducing an easy, rapid, high throughput, low-cost, and efficient identification technique. This technology has been adapted to the constraint of clinical diagnostic laboratories and has the potential to replace and/or complement conventional identification techniques for both bacterial and fungal strains. Using standardized procedures, the resolution of MALDI-TOF MS allows accurate identification at the species level of most Gram-positive and Gram-negative bacterial strains with the exception of a few difficult strains that re...