Contraceptive effectiveness and safety of five nonoxynol | 合法醫療器材資訊網

由EGRaymond著作·2004·被引用60次—Contraceptiveeffectivenessandsafetyoffivenonoxynol-9spermicides:arandomizedtrial...Methods:Womenwishingtouseonlyspermicideforcontraceptionfor7...DosageForms;SpermatocidalAgents;Suppositori

Objectives: To estimate and compare the effectiveness and safety of 5 spermicides over 6 and 7 months of use, respectively. The spermicides included 3 gels containing 52.5 mg, 100 mg, and 150 mg of nonoxynol-9 per dose and a film and a suppository, each containing 100 mg of nonoxynol-9 per dose.

Methods: Women wishing to use only spermicide for contraception for 7 months were randomly assigned to use 1 of the 5 spermicides with emergency contraception backup. Participants were followed up for up to 30 weeks after admission.

Results: Of 1,536 women enrolled, 868 (57%) either relied on the spermicide for 6 months or became pregnant. The probability of pregnancy during 6 months of typical use of the spermicide was 22% (95% confidence limits 16%, 28%) in the 52.5-mg gel group, 16% (10%, 21%) in the 100-mg gel group, 14% (9%, 19%) in the 150-mg gel group, 12% (7%, 17%) in the film group,...