Prostate cancer markers: An update | 合法醫療器材資訊網

由SPENTYALA著作·2016·被引用46次—2.Diagnosticandprognosticmarkers·Prostaticacidphosphatase(PAP)·PSA·hK2·Insulin-likegrowthfactor-1(IGF-1)andinsulin-likegrowth ...

In terms of biochemical markers, the first to be used routinely in the diagnosing and staging of prostate cancer was PAP. PAP hydrolyzes esters under acidic conditions to yield inorganic phosphates. Although identified in numerous organs such as the liver, brain and lungs, the highest concentration of PAP is identified in the prostate. Prostate epithelial cells secrete PAP into the glandular lumen and can be measured by either immunoassay or enzymatic assay.

A 1938 study showed PAP to be elevated in the prostates of patients with metastatic prostate cancer (5). However, a subsequent study showed that PAP levels in prostate cancer tissue were only a fraction of those identified in patients with BPH (6). Furthermore, in a study that evaluated PAP levels in 102 patients, 84% of patients that had eleva...