Effects of inhaled hypertonic (7%) saline on lung function test ... | 合法醫療器材資訊網

由RNenna著作·2017·被引用11次—Themostcommonadverseeventexpectedwiththeintroductionofthetherapywerecough,throatirritationandunpleasantsaltytaste[2].Inour ...

The present double-blind, randomized crossover study on 12 preschool children with cystic fibrosis, in clinically stable conditions, shows that the inhalation of HS twice daily is a safe treatment. To our knowledge, this is the first study testing Rint technique, an objective measurement of lung function in this range age [10, 12,13,14], over a course of HS treatment in children with cystic fibrosis. Our data, seems to confirm, on a little young population in the early phase of lung involvement, the short and middle-term benefits of HS, widely described in literature on adult patients [1, 2, 7, 15, 16]. In fact, a significant improvement of spirometric parameters was registered after 16-week HS therapy, while a worsening of those parameters was found in NS group. Similarly, Rosenfeld et al. have demonstrated a significant improvement of FEV0.5 in the group of 7% HS children younger than 6 years with cystic fibrosis, even if a reduction of pulmonary exacerbations was not reached [6]....