CA | 合法醫療器材資訊網

Structure[edit]...Mucin16isamembraneassociatedmucinthatpossessesasingletransmembranedomain....AuniquepropertyofMUC16isitslargesize.MUC16 ...

CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein that in humans is encoded by the MUC16 gene.[3][4] MUC16 is a member of the mucin family glycoproteins.[5] CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers,[6] or other conditions that are benign.

Structure[edit]

Mucin 16 is a membrane associated mucin that possesses a single transmembrane domain.[7] A unique property of MUC16 is its large size. MUC16 is more than twice as long as MUC1 and MUC4 and contains about 22,000 amino acids, making it the largest membrane-associated mucin.[8]

MUC16 is composed of three different domains:[9]

The N-terminal and tandem repeat domains are both entirely extracellular and highly O-glycosylated. All mucins contain a tandem repeat domain that has repeating amino acid sequences high in serine, threonine and...

MUC16 Gene - GeneCards | 合法醫療器材資訊網

MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include Ovarian Cyst and Clear Cell Adenocarcinoma. Read More

MUC16 - Mucin-16 | 合法醫療器材資訊網

MUC16. Organism. Homo sapiens (Human). Status. Reviewed-Annotation score: ... MUC-16. Alternative name(s):. Ovarian cancer-related tumor marker CA1251 ... Read More

MUC16 as a Novel Target for Cancer Therapy | 合法醫療器材資訊網

由 A Aithal 著作 · 2018 · 被引用 56 次 — MUC16 is a large cell surface molecule that plays a protective role at the apical surface of normal epithelia. Although its increased expression ... Read More

94025 | 合法醫療器材資訊網

7 天前 — MUC16 is the major [(35)S]sulphate-labelled mucin in normal human bronchial epithelial cell secretions. Measurement of CA 15-3 serum values ... Read More

Mucin 16 (cancer antigen 125) expression in human tissues ... | 合法醫療器材資訊網

由 MM Streppel 著作 · 2012 · 被引用 113 次 — MUC16 is the largest TM mucin and is used worldwide for monitoring patients with ovarian cancer [4,8]. Several research groups have attempted ... Read More

CA | 合法醫療器材資訊網

Structure[edit] ... Mucin 16 is a membrane associated mucin that possesses a single transmembrane domain. ... A unique property of MUC16 is its large size. MUC16 ... Read More

MUC16 (CA125) | 合法醫療器材資訊網

由 M Felder 著作 · 2014 · 被引用 290 次 — Molecular cloning of MUC16 revealed it to be a mucinous glycoprotein with an average molecular weight between 3–5 million Da [21, 22, 71, ... Read More

MUC16 protein expression summary | 合法醫療器材資訊網

MUC16 (CA125, FLJ14303) protein expression summary. ... Gene name, MUC16 (HGNC Symbol). Synonyms, CA125, FLJ14303. Description, Mucin 16, cell ... Read More

MUC16 | 合法醫療器材資訊網

CA-125 (also known as mucin 16 or MUC16) is a glycoprotein. CA-125 in humans is encoded by the MUC16 gene. CA-125 is used as a tumor marker because CA ... Read More

MUC16 suppresses human and murine innate immune ... | 合法醫療器材資訊網

由 M Felder 著作 · 2019 · 被引用 17 次 — For the first time, we demonstrate the immunoregulatory effects of MUC16 on murine NK cells and macrophages. Our study implies that the ... Read More

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