Optimal Intensity of Warfarin Therapy in Patients With ... | 合法醫療器材資訊網

由KKido著作·2019·被引用2次—TheINRgoalsof2to3forlowriskand2.5to3.5forhighriskshouldbeconsideredforbileafletmechanicalaorticvalverecipients.Additionally ...

Objective:: To review the current guidelines and published literature in order to identify the evidence-based international normalized ratio (INR) goal in patients with a mechanical aortic valve.

Data sources:: Medline/PubMed, Cochrane and Google Scholar database searches for relevant articles from 1946 through March 2017 were executed using the key words "mechanical aortic valve" and "antithrombotic therapy or anticoagulation therapy or warfarin."

Study selection and data extraction:: All English-language observational and interventional studies assessing INR goals in patients with a mechanical aortic valve were evaluated.

Results:: After low thrombogenic valves became standard in the practice, the INR goal decreased to 2 to 3 in low-risk recipients with most of bileaflet mechanical aortic valves. There is a paucity of data to justify the INR goal of 2 to 3 in high...