Human Chorionic Gonadotropin (hCG) | 合法醫療器材資訊網

2019年11月19日—ReferenceRange·Negative:<5IU/L·Indeterminate:5-25IU/L·Positive:>25IU/​L.

Human chorionic gonadotropin (hCG) is a dimer consisting of a 145 amino acid beta-subunit that is unique to hCG and a 92 amino acid alpha-subunit. The alpha-subunit is identical to that for luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH). The alpha and beta-subunits have separate genes on separate chromosomes (chromosomes 6 and 19, respectively). After synthesis, the alpha and beta-subunits are bonded with a noncovalent bond before being released into the circulation.

Carbohydrate side chains comprise 25-40% of the molecular weight of hCG. The alpha-subunit contains 2 N-linked oligosaccharides; the beta-subunit contains 2 N-linked oligosaccharides, as well as 4 O-linked oligosaccharides on the C-terminal extension. The 2 most common forms of hCG synthesized by cells are regular hCG and hyperglycosylated hCG (hCG-H). HCG-H contains more sugar residues than regular hCG: 1....