The cell proliferation antigen Ki | 合法醫療器材資訊網
由MSobecki著作·2016·被引用167次—AntigenKi-67isanuclearproteinexpressedinproliferatingmammaliancells.Itiswidelyusedincancerhistopathologybutitsfunctionsremainunclear.Here ...
Essential revisions: One remaining concern is with the H3K9 and K4K20 data that leads the authors to conclude "trimethylation of histone H3K9 and H4K20 at heterochromatin is strongly reduced" in the abstract. Looking at the data, in Figure 10—figure supplement 1, this is not apparent. It does seem reduced, but it is hard to tell. The authors could do some quantification here as they have done for some of the other microscopy-based data. A result featured so strongly in the Abstract should be backed by clear data. Either the authors should tone down the Abstract and put the caveats in the paper, or bolster these data.
We would argue that the statement in the Abstract was technically correct – that H3K9 and H4K20 is strongly reduced at heterochromatin (though it is not changed in overall levels). For example, in Figure 10A, the H3K9me3 no longer colocalises with the intense DAPI spots th...
4288 | 合法醫療器材資訊網
Ki | 合法醫療器材資訊網
Ki | 合法醫療器材資訊網
Ki-67: more than a proliferation marker | 合法醫療器材資訊網
Ki | 合法醫療器材資訊網
Ki67 is a Graded Rather than a Binary Marker of Proliferation ... | 合法醫療器材資訊網
MKI67 Gene - GeneCards | 合法醫療器材資訊網
The cell proliferation antigen Ki | 合法醫療器材資訊網
The hippo pathway effector Yes | 合法醫療器材資訊網
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