Evolution of Pap Stain | 合法醫療器材資訊網

由KRaju著作·2016·被引用14次—Papstainingprocedureisclassifiedintotwotypesi.eprogressiveandregressivemethod.Inprogressivemethodthenucleusisstainedtothe ...

Pap stain is a universal stain used for gynecologic and non-gynecologic cytology smear. It is mainly used for oral and cervical cancer screening in asymptomatic population and in the follow up of patients with cancer. Pap test has decreased incidence of cervical cancer by 70% in developed countries. Pap stain yields polychromatic transparent staining reaction with crisp nuclear and cytoplasmic features (Asthana A, 2014; RoyBiswas et al., 2008).

Pap stain was developed by Greek doctor George Nicholas Papanicoloau at Cornell medical college of New York to know the variation in cellular maturity and metabolic activity in vaginal smears. The original pap stain was published in 1942 and later it was modified by Dr. Papanicoloau in 1954 and 1960 (Asthana A, 2014; Bales, 2006; GN, 1960; Papanicolaou, 1942, 1954). Since the introduction of pap stain by G.N. Papanicoloau it has undergone various modifications (Asthana A, 2014).

The principle of pap stain...