Cardiac Enzymes | 合法醫療器材資訊網

由SPatibandla著作·2020·被引用5次—CK-MBstillholdssomediagnosticvalueincardiacandnon-cardiacconditions.CK-MBisdetectedintheserum4hoursaftermyocardialinjury, ...

Cardiac enzymes have been in use since the mid 20th century in evaluating patients with suspected acute myocardial infarction (MI). The biomarkers used back then are not clinically relevant today as more sensitive and specific biomarkers have replaced them. Troponins are the most widely recognized and important cardiac enzymes used in the diagnosis of acute myocardial ischemia in modern medicine. The majority of patients with an acute MI will have elevation in troponins within 2 to 3 hours of arrival at the emergency department, versus 6 to 12 hours with creatine kinase.

The first biomarker used to aid in the diagnosis of acute MI was aspartate aminotransferase (AST). In 1954, Ladue et al. proposed that AST released from cardiomyocytes undergoing necrosis would be useful in diagnosing acute MI.[1] AST increases in the blood 3 to 4 hours after an ...