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由JSpaargaren著作·1998·被引用58次—Itwasshownthattheactivitiesofsomegenerallyusedantibioticsdecreasedby80to90%within2hinBactecPlusAerobic/Fresin-containingculturemedium.

Incorporating resins in blood culture media can effectively reduce the activities of several antibiotics. It was shown that the activities of some generally used antibiotics decreased by 80 to 90% within 2 h in Bactec Plus Aerobic/F resin-containing culture medium. Bactec vials containing resins were still found to be positive for bacteria when antibiotics were present. The addition of β-lactamase shortened the detection time irrespective of the presence of resins.

The empirical initiation of antibiotic treatment before carrying out blood cultures is known to suppress or slow the recovery of microorganisms from the blood. The dilution of the blood sample in culture medium, the addition of antibiotic-inactivating enzymes to the blood culture, and a lysis centrifugation method have been reported to enhance the recove...