Leukodepletion blood filters | 合法醫療器材資訊網

由SDzik著作·1993·被引用170次—Leukodepletionbloodfilters:filterdesignandmechanismsofleukocyteremoval.TransfusMedRev.1993Apr;7(2):65-77.doi:10.1016/s0887-7963(93)70125-x.

Modern leukocyte removal filters have been developed after years of refinement in design. Current filters are composite filters in which synthetic microfiber material is prepared as a nonwoven web. The filter material may be surface modified to alter surface tension or charge to improve performance. The housing design promotes effective contact of blood with the filter material and decreases shear forces. The exact mechanisms by which these filters remove leukocytes from blood components are uncertain, but likely represent a combination of both physical and biological processes whose contributions to leukocyte removal are interdependent. Small-pore microfiber webs result in barrier phenomena that permit retention of individual cells and increase the total adsorptive area of the filter. Modifications in surface charge can increase or decrease cell attraction to the fibers. Optimum interfacial surface tensions between...