Performance of the Etest for Susceptibility Testing of ... | 合法醫療器材資訊網

由MKresken著作·2018·被引用8次—Ceftazidime-avibactam(CZA)isanewerβ-lactam–β-lactamaseinhibitorcombinationwithinvitroactivityagainstGram-negativebacteria, ...

Ceftazidime-avibactam (CZA) is a newer β-lactam–β-lactamase inhibitor combination with in vitro activity against Gram-negative bacteria, including a range of carbapenemase-producing organisms (1). Quantitative MIC data are often necessary for the management of infections in critical care patients. MIC gradient tests are particularly valuable in these situations.

We compared the performance of the CZA Etest (bioMérieux SA, Marcy lEtoile, France) with that of the reference broth microdilution (BMD) method against 200 Gram-negative bacteria, of which 140 were Enterobacterales strains (including 28 extended-spectrum-β-lactamase [ESBL]-producing organisms, 20 carbapenemase-producing organisms, and 3 organisms coproducing an ESBL and a carbapenemase) and 60 Pseudomonas aeruginosa strains (including 18 carbapenemase-producing organisms). BMD MICs of imipenem and meropenem for...