Glycated hemoglobin | 合法醫療器材資訊網

Glycatedhemoglobin(glycohemoglobin,HbA1c,hemoglobinA1c,A1c,orlesscommonlyHbA1c,HgbA1c,Hb1c,etc.)isaformof·Theformationofthesugar- ...

Form of hemoglobin chemically linked to a sugar

Glycated hemoglobin (HbA1c, glycohemoglobin, glycosylated hemoglobin,hemoglobin, A1C or A1c) is a form of hemoglobin (Hb) that is chemically linked to a sugar. Most monosaccharides, including glucose, galactose and fructose, spontaneously (i.e. non-enzymatically) bond with hemoglobin when present in the bloodstream. However, glucose is less likely to do so than galactose and fructose (13% that of fructose and 21% that of galactose), which may explain why glucose is used as the primary metabolic fuel in humans.[1][2]

The formation of the sugar-hemoglobin linkage indicates the presence of excessive sugar in the bloodstream, often indicative of diabetes in high concentration (HbA1c >6.4%).[3] A1C is of particular interest because it is easy to detect. The process by which sugars attach to hemoglobin is called glycation and the reference sy...