Cystatin C measurement and its practical use in patients with ... | 合法醫療器材資訊網

由STian著作·1997·被引用206次—ThesedatasuggestthatcombinedmeasurementofcystatinCintheserumand...rateoflowmolecularweightproteinwithdifferenttypesofhighfluxmembr…...forglomerularfiltrationrate(GFR),wedeterminedthe

Objective: To evaluate the clinical usefulness in terms of estimation for glomerular filtration rate (GFR), we determined the cystatin C levels in the serum and urine of 33 healthy volunteers as well as in the serum and urine of 35 patients with various renal diseases and compared them with those of creatinine. In addition, we evaluated this substance as an indicator of removal rate of low molecular weight protein with high flux membranes in 6 hemodialysis (HD) patients.

Methods: Serum and urinary cystatin C levels were measured by using an enzyme-linked immunosorbent assay (ELISA) method, 24-hour creatinine clearance was used as an indicator of GFR.

Results: Reference intervals with 95% ranges are 0.47-1.03 mg/l in the serum from healthy volunteers. There was a significant positive correlation between serum cystatin C and creatinine levels (r = 0.936, p < 0.001) in the patients ...