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MUC16isamemberofthemucinfamilyglycoproteins....CA-125hasfoundapplicationasatumormarkerorbiomarkerthatmaybeelevatedinthebloodofsome ...

CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein that in humans is encoded by the MUC16 gene.[3][4] MUC16 is a member of the mucin family glycoproteins.[5] CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers,[6] or other conditions that are benign.

Mucin 16 is a membrane associated mucin that possesses a single transmembrane domain.[7] A unique property of MUC16 is its large size. MUC16 is more than twice as long as MUC1 and MUC4 and contains about 22,000 amino acids, making it the largest membrane-associated mucin.[8]

MUC16 is composed of three different domains:[9]

The N-terminal and tandem repeat domains are both entirely extracellular and highly O-glycosylated. All mucins contain a tandem repeat domain that has repeating amino acid sequences high in serine, threonine and...