NGS DNA Target Enrichment | 合法醫療器材資訊網

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Target enrichment is a cost-effective and efficient method for researchers to capture specific regions of interest after library preparation for NGS and has many advantages over whole genome sequencing (WGS).

Target enrichment enables focused sequencing resources, which leads to reduced cost and simplified analysis.1 The technique increases the probability of sequencing DNA fragments of the targeted regions compared to all other genes or regions in the genome. As a result, the rest of the genome can be disregarded, simplifying downstream bioinformatics analysis. It also provides greater sequencing depth, which helps prevent false interpretations of sequencing data. Furthermore, it increases the ability of NGS to detect variants from limited sample amounts and increases sensitivity. Because of this sequencing depth and sensitivity, target enrichment is valuable in variant calling in cancer research, iden...