The effect of seprafilm and interceed on capsule formation ... | 合法醫療器材資訊網

由HFriedman著作·2004·被引用21次—Theinsertionofaforeignsubstance,suchasabreastimplantintomammaliansofttissues,evokesawoundhealingresponsethatculminatesinadense ...

The insertion of a foreign substance, such as a breast implant into mammalian soft tissues, evokes a wound healing response that culminates in a dense connective-tissue envelope or capsule surrounding the implant. Several biodegradable products, such as Seprafilm (carboxymethylcellulose and hyaluronic acid) and Interceed (oxidized regenerated cellulose), have been demonstrated to inhibit adhesions in abdominal and gynecologic surgery. The ability of these cellulose compounds to inhibit capsule formation was addressed in this investigation. Twenty-eight rats were implanted intermuscularly with either plain silicone discs (10 animals), discs wrapped in Seprafilm (10 animals), or discs covered with Interceed (8 animals). Additional control animals (6 animals) consisted of two that had sham operations, two animals implanted with Seprafilm only, and two more implanted with Interceed only. Animals were sacrificed in pairs...