Heterotopic ossification | 合法醫療器材資訊網

Heterotopic ossification refers to the presence of bone in soft tissue where bone normally does not exist (extraskeletal bone). Lesions range from small clinically insignificant foci of ossification to large deposits of bone that cause pain and restriction of function.

The most common presentation is with pain around the ossification site. Associated features can include fever, soft tissue swelling, and poor mobility of the affected joint.

The pathophysiology is unknown but most theories describe a cellular response to local tissue injury which leads to the release of chemical mediators that stimulate exaggerated bone proliferation. Muscle trauma seems to be a significant triggering event. Heterotopic ossification is histologically identical to normal cortical and cancellous bone.

Acquired heterotopic ossification can be secondary to:

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