The effect of 2 sealants (FloSeal and Tisseel) on ... | 合法醫療器材資訊網

由SJorgensen著作·2003·被引用28次—TheFloSealandTisseeldemonstratenoshort-termdetrimentaleffectonflapsurvivalnordotheyseemtoaffectrevascularizationinafasciocutaneousfreeflap ...

Background: Fasciocutaneous tissue transfer is one of the most common procedures performed in head and neck reconstructive surgery. These composite tissues can be transferred as either a free flap or a pedicled flap. Free tissue transfer has become the reconstructive modality of choice following head and neck oncologic ablation. Synthetic tissue adhesives and hemostatic agents are rapidly gaining popularity in reconstructive surgery. Their ability to decrease bleeding and promote flap sealing and healing has led to a proliferation in their use. To our knowledge, the short-term effect of these substances on healing, as measured by flap revascularization, has not been systematically investigated.

Methods: Fifty-six male Sprague-Dawley rats were divided into 3 groups: a control group, a matrix hemostatic sealant (FloSeal) group, and a 2-component fibrin sealant (Tisseel) group. In each group, the r...