Glossary | 合法醫療器材資訊網

ThefantigenispresentwhenapersoninheritsanRHCEallelethatcodesforboththe...Thefantibody(anti-f)actsmuchlikeotherRhantibodies,withevidenceofhemolyticdiseaseofthefetus/newborn(HDFN)andpossiblehemolytictransfusionreacti

NOTE: Before you read this entry, you should be very familiar with the genetics and terminology in the Rh Blood Group System. If you don’t feel comfortable with “Rh haplotypes” and what they mean, you should read my blog post on Rh terminology[1] first, then come back here.

The antigen known as “f” has historically been described as a “compound antigen” in the Rh blood group system. The f antigen is present when a person inherits an allele of the RHCE gene that codes for both the c and e antigens (specifically, the RHCE*ce allele of the RhCE gene), and absent if the person does not inherit that allele (i.e., if the person inherits only some combination of the other three RHCE alleles: RHCE*Ce, RHCE*cE, or the very uncommon RHCE*CE). With me so far? Hang in there, and go review the blog post above if that doesn’t make sense.

When we use the “Modified Wiener” shorthand terminology to describe someone’s Rh genotype (you know, the “R1, R2, R0, r” stuff you learned in the p...