ACTH Stimulation Test (Cosyntropin) | 合法醫療器材資訊網

Interpretation:Arisefromthebaselineofatleast7μg/dLto10μg/dLofcortisol,reachingatleast18μg/dLat60minutespoststimulationeffectivelyrulesout ...

Purpose: Evaluation of possible primary or secondary adrenal insufficiency, as well as disorders of adrenal steroid biosynthesis, such as congenital adrenal hyperplasia (CAH).1,2

Rationale: Cosyntropin, (ACTH 1-24), consists of the first 24 amino acids of the N-terminal portion of the intact native ACTH molecule (ACTH 1-36). This portion comprises the biologically active region of intact ACTH and is less allergenic than other forms of ACTH. It acts rapidly when bound to the melanocortin-2 receptor (MC2R) of the adrenal cortex initiating synthesis and release of cortisol and its precursors by 30 minutes3 and a saturating pulse dose is believed to act for at least two hours.4The magnitude and duration of response as measured by serum steroid levels may depend on the prior stimulation or suppression of the hypothalamic-pituitary-adrenal axis and the adequacy of drug administration. N...