HercepTest for the Detection of HER2 Protein Overexpression ... | 合法醫療器材資訊網

2011年9月20日—TheHercepTestkitisasafeandreliablemethodtodetermineHER2proteinoverexpressioninbreastandgastriccancers.TheASCOandCAP ...

Breast cancer is the most common type of cancer among females in the United States. In 2007, 202,964 women in the U.S. were diagnosed with breast cancer.1 In 20% to 30% of breast cancers, there is an overexpression of human epidermal growth factor receptor 2 (HER2), which is a protein that normal breast epithelial tissue expresses in low levels.2 Similarly, there is an overexpression in gastric cancers. Overexpression of HER2 allows for the transmission of growth signals, which alter normal cell growth and division and have been associated with increased tumor aggressiveness and recurrence risk. 

Trastuzumab (Herceptin) is a monoclonal antibody that targets the HER2 receptor protein through antibody-dependent cellular cytotoxicity. Trastuzumab demonstrates decreased mortality rates in HER2-positive breast and gastric cancers when administered with chemothe...