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由AKozlovsky著作·2009·被引用91次—TheuseofadoublelayerofBGmembraneresultsinabarrierofincreased...Bio​-degradationofaresorbablecollagenmembrane(Bio-Gide)...wassimilarfortheDLMandMLMatbothtimepoints(approximately60

Objective: The aim of this study was to evaluate histologically the bio-degradation of two layers of Bio-Gide((R)) (BG) membrane, as compared with that of a single layer.

Material and methods: Two circular calvarial bony defects, 5 mm in diameter, were made in 24 Wistar rats. BG membrane, labeled with biotin, was cut into 5-mm-diameter disks, and placed in defects either as a mono-layer membrane (MLM) or as a double-layer membrane (DLM). Rats were sacrificed after 4 or 9 weeks and histology was performed. Membranes were stained with horseradish peroxidase-conjugated streptavidin and aminoethyl carbazole as a substrate for detection of biotinylated collagen. The area of collagen and thickness of the residual membranes were measured by image analysis software. Statistical analysis was performed using the non-parametric Wilcoxons signed-ranks test.

Results: At 4-week collagen area per ...