VerifyNow P2Y12 and VerifyNow PRU Test | 合法醫療器材資訊網

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Platelet Function Testing: VerifyNow Assays

1. The VerifyNow-P2Y12 Assay/VerifyNow PRU Test The VerifyNow-P2Y12 Assay/VerifyNow PRU Test is a rapid test that uses ADP to stimulate platelets in the presence of PGE1 [Prostaglandin E1] and which inhibits activation downstream of a second ADP receptor P2Y1 - making the assay more sensitive and specific for the activity of the P2Y12 receptor and of drugs that bind to the P2Y12 receptor. The assay system reagent is designed to specifically measure P2Y12 - mediated platelet aggregation.

There are two principal ADP receptors on the surface of the platelets: a. P2Y1 :  P2Y1 is a G-coupled receptor that initiates ADP-induced platelet aggregation through stimulation of Phospholipase C and the Phosphatidylinositol-signaling pathway. b. P2Y12 : P2Y12 is a G-coupled seven-transmembrane domain rec...